Breast Cancer

Trial ANTHEM
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

The ANTHEM Feasibility Study, Is A Novel THErapeutic mammaplasty procedure a safe and effective alternative to Mastectomy for treatment of breast cancer?

Trial ASTEFANIA
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
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A phase III, randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of adjuvant atezolizumab or placebo and trastuzumab emtansine for her2-positive breast cancer at high risk of recurrence following preoperative therapy

Trial KEYNOTE-B49
Cancer Type Breast Cancer
Hospital(s) Altnagelvin Hospital
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A Randomised, Double-blind, Placebo-controlled, Phase 3 Study of Pembrolizumab Plus Chemotherapy Versus Placebo Plus Chemotherapy for the Treatment of Chemotherapy-Candidate Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (HR+/HER2-) Metastatic Breast Cancer

Trial NERELYFE Study
Cancer Type Breast Cancer
Hospital(s) Altnagelvin Hospital
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Multicenter, multi-country, prospective, observational, post authorisation safety study to describe the incidence of discontinuation due to diarrhoea within the first 3 months of treatment with neratinib, in adult breast cancer patients treated in extended adjuvant in a real world setting: the NERLYFE study. Ancillary study: A Nerlyfe ancillary study to describe recurrence in breast cancer patients treated with neratinib in a real-world setting

Trial NOSTRA
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
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A prospective, non-randomised, multi-centre feasibility study to assess if patients residual cancer following dual-targeted neoadjuvant chemotherapy treatment for HER2-positive, ER-negative early breast cancer can be identified by multiple ultrasound-guided tumour bed core biopsies

Trial OPTIMA
Cancer Type Breast Cancer
Hospital(s) Ulster Hospital
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Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis

Trial PEARL
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
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A window of opportunity study to assess the biological effects of progesterone in premenopausal ER-positive, PgR-positive early breast cancer

Trial PIONEER (Breast cancer)
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
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Randomised Phase II clinical trial PIONEER- A Pre-operative wIndOw study of Letrozole plus PR agonist (Megestrol Acetate) versus Letrozole aloNE in post-menopausal patients with ER-positive breast cancer

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Trial RESTORE-C19
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
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Exploring the experiences and outcomes of patients not offered immediate breast REconstruction after maSTectOmy for bREast cancer during the COVID-19 pandemic

Trial ROSCO
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
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Response To Optimal Selection Of Neo-Adjuvant Chemotherapy In Operable Breast Cancer

Trial SMALL Trial
Cancer Type Breast Cancer
Hospital(s) Altnagelvin Hospital, Belfast City Hospital, and Craigavon Hospital
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A Phase III, randomised, multi-centre trial addressing overtreatment of small screen-detected breast cancer by comparing standard surgery versus minimally invasive vacuum-assisted excision