Belfast City Hospital

Trial Add-Aspirin Trial
Cancer Type Gastrointestinal, Genitourinary, Miscellaneous, Oesophageal Cancer, Prostate Cancer, Stomach Cancer, and Non-specific
Hospital(s) Belfast City Hospital
Information

A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours

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Trial AMPLITUDE
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A Phase 3 Randomized, Placebo-controlled, Double-blind Study of Niraparib in Combination with Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants with Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Trial ANTHEM
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
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The ANTHEM Feasibility Study, Is A Novel THErapeutic mammaplasty procedure a safe and effective alternative to Mastectomy for treatment of breast cancer?

Trial ASTEFANIA
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
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A phase III, randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of adjuvant atezolizumab or placebo and trastuzumab emtansine for her2-positive breast cancer at high risk of recurrence following preoperative therapy

Trial CellCentric
Cancer Type Miscellaneous and Non-specific
Hospital(s) Belfast City Hospital
Information

An open-label Phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination in patients with advanced solid/metastatic tumours

Trial CellCentric CCS1477-01
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

An open-label Phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination in patients with advanced solid/metastatic tumours

Trial COMPARE
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
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Phase III randomised controlled trial Comparing Alternative Regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer

Trial CONCORDE
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

A platform study of DNA damage response inhibitors in combination with conventional radiotherapy in non small cell lung cancer

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Trial DASL-HiCaP
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate (ANZUP1801). A randomised phase 3 double-blind, placebo-controlled trial of adding darolutamide to androgen deprivation therapy and definitive or salvage radiation in very high risk, clinically localised prostate cancer

Trial DIAdIC
Cancer Type Miscellaneous and Non-specific
Hospital(s) Belfast City Hospital
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Protocol for an International Randomized Controlled Trial to evaluate the effectiveness of a nurse-delivered (FOCUS+) and a web-based (iFOCUS) psychoeducational intervention for people with Advanced cancer and their family caregivers

Trial DRAGON 1
Cancer Type Bowel Cancer
Hospital(s) Belfast City Hospital
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Training, Accreditation, Implementation And Safety Evaluation Of Portal and Hepatic Vein Embolization (PVE/HVE) To Accelerate Future Liver Remnant (FLR) Hypertrophy

Trial FEDORA
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
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A Phase II Study To Evaluate The Tolerability, Safety And Activity Of Fedratinib Combined With Ropeginterferon Alfa-2b In Patients With Myelofibrosis

Trial FLAIR
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Altnagelvin Hospital, Belfast City Hospital, and Craigavon Hospital
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Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab

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Trial frontMIND
Cancer Type Haematological Cancers and Lymphoma
Hospital(s) Belfast City Hospital
Information

A phase 3, multicenter, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of tafasitamab plus lenalidomide in addition to R-CHOP versus R-CHOP in previously untreated, high-intermediate and high-risk patients with newly diagnosed diffuse large B-cell lymphoma

Trial HALT
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

Targeted therapy with or without dose intensified radiotherapy for oligo-progressive disease in oncogene-addicted lung tumours

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Trial ICHOR
Cancer Type Gastrointestinal, Oesophageal Cancer, and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

Investigation of Circulating Haematological Biomarkers in Cancer

Trial Immune gene expression and tumour microenvironment in prostate cancer
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
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How does radiotherapy affect immune gene expression and the tumour microenvironment in men with localised prostate cancer?

Trial IMPARTER:4
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
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IMproving PAtient undeRstanding of GEP TEst Results: Phase 4

Trial iNATT
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
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The interNational Anaplastic Thyroid Cancer Tissue Bank and Database Project

Trial M16-109
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
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A Phase II Open-Label Study Evaluating Tolerability And Efficacy of Navitoclax Alone or In Combination With Ruxolitinib in Subjects With Myelofibrosis

Trial M19-708 / VIALE-M
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

Randomized, Open-Label, 2-Arm, Multicenter, Phase 3 Study Of Venetoclax and Azacitidine Versus Best Supportive Care As Maintenance Therapy For Patients With Acute Myeloid Leukemia In First Remission After Conventional Chemotherapy

Trial MONITOR-UK
Cancer Type Gynaecological and Ovarian Cancer
Hospital(s) Belfast City Hospital
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Multi-Centre Observational study of Maintenance Niraparib in Treatment of Ovarian CanceR: UK routine clinical practice experience

Trial MOSAICC
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Altnagelvin Hospital, Antrim Hospital, Belfast City Hospital, Craigavon Hospital, and Ulster Hospital
Information

MyeloprOliferative NeoplasmS An In-Depth Case-Control Study: A Case-Control Study Of Patients With Myeloproliferative Neoplasms And Non-Blood Relative/Friend Controls

Trial NOSTRA
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
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A prospective, non-randomised, multi-centre feasibility study to assess if patients residual cancer following dual-targeted neoadjuvant chemotherapy treatment for HER2-positive, ER-negative early breast cancer can be identified by multiple ultrasound-guided tumour bed core biopsies

Trial PACE
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
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Patients with AML and COVID-19 Epidemiology

Trial PEARL
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

A window of opportunity study to assess the biological effects of progesterone in premenopausal ER-positive, PgR-positive early breast cancer

Trial Pivotal Boost
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
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A Phase III Randomised Controlled Trial of Prostate and Pelvis Versus Prostate Alone Radiotherapy With Or Without Prostate Boost

Trial PLATFORM
Cancer Type Oesophageal Cancer and Stomach Cancer
Hospital(s) Belfast City Hospital
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PLAnning Treatment For Oesophago-Gastric Cancer: a Randomised Maintenance Therapy Trial

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Trial PLATFORM
Cancer Type Gastrointestinal, Oesophageal Cancer, and Stomach Cancer
Hospital(s) Belfast City Hospital
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PLAnning Treatment For Oesophago-Gastric Cancer: a Randomised Maintenance Therapy Trial

Trial POETIC-A
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Pre-Operative Endocrine Therapy for Individualised Care with Abemaciclib

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Trial PORCUPINE 2 STUDY
Cancer Type Gastrointestinal, Miscellaneous, and Pancreatic Cancer
Hospital(s) Belfast City Hospital
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A Modular, Phase II, Open-Label, Multicentre Study to Assess the Preliminary Efficacy and Safety of RXC004, in Patients with Advanced Solid Tumours that have Progressed following Therapy with Current Standard of Care

Trial Precision-Panc
Cancer Type Gastrointestinal and Pancreatic Cancer
Hospital(s) Belfast City Hospital
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Master Protocol Personalising Treatment For Pancreatic Cancer

Trial PRIMUS-001
Cancer Type Gastrointestinal and Pancreatic Cancer
Hospital(s) Belfast City Hospital
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An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation

Trial PROMISE
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
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Investigation Into The Combination Of PLX2853 With Ruxolitinib In Patients With Intermediate-2 Or High Risk Myelofibrosis Not Receiving An Adequate Response With Ruxolitinib Alone

Trial PROTECTOR
Cancer Type Gynaecological and Ovarian Cancer
Hospital(s) Belfast City Hospital
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Preventing Ovarian Cancer through Early Excision of Tubes and late Ovarian Removal

Trial PSMAddition
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
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An International Prospective Open-Label, Randomised, Phase 3 Study Comparing 177Lu-PSMA-617 In Combination With Standard of Care, Versus Standard Of Care Alone, In Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer

Trial RANGO
Cancer Type Cervical Cancer, Endometrial (womb) Cancer, Gynaecological, Ovarian Cancer, and Vulval Cancer
Hospital(s) Belfast City Hospital
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Rare Neoplasms of Gynaecological Origin

Trial RAPPER
Cancer Type Miscellaneous
Hospital(s) Belfast City Hospital
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Radiogenomics: Assessment of Polymorphisms For Predicting The Effects of Radiotherapy

Trial RE-ARM
Cancer Type Bladder Cancer
Hospital(s) Belfast City Hospital
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A Randomised phase II trial of Enhancement of efficacy of Atezolizumab by Radiotherapy in Metastatic urothelial carcinoma

Trial RESTORE-C19
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
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Exploring the experiences and outcomes of patients not offered immediate breast REconstruction after maSTectOmy for bREast cancer during the COVID-19 pandemic

Trial ROSCO
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Response To Optimal Selection Of Neo-Adjuvant Chemotherapy In Operable Breast Cancer

Trial SCOPE 2
Cancer Type Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

A randomised Phase II/III trial to study radiotherapy dose escalation in patients with
oesophageal cancer treated with definitive chemo-radiation with an embedded Phase II trial for patients
with a poor early response using positron emission tomography (PET)

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Trial SCOPE 2
Cancer Type Gastrointestinal and Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

A randomised Phase II/III trial to study radiotherapy dose escalation in patients with oesophageal cancer treated with definitive chemo-radiation with an embedded Phase II trial for patients with a poor early response using positron emission tomography (PET)

Trial SMALL Trial
Cancer Type Breast Cancer
Hospital(s) Altnagelvin Hospital, Belfast City Hospital, and Craigavon Hospital
Information

A Phase III, randomised, multi-centre trial addressing overtreatment of small screen-detected breast cancer by comparing standard surgery versus minimally invasive vacuum-assisted excision

Trial Stampede
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
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Systemic Therapy in Advancing or Metastatic Prostate cancer – Evaluation of Drug Efficacy

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Trial STELLAR
Cancer Type Haematological Cancers and Lymphoma
Hospital(s) Belfast City Hospital
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A phase II, randomiSed study of CHOP-R in combination with acalabruTinib comparEd to CHOP-R in patients with newLy diagnosed Richter’s Syndrome and a pLAtfoRm for initial investigations into activity of novel treatments in relapsed/refractory and newly diagnosed Richter’s Syndrome

Trial TARGET-National
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

Tumour Characterization to Guide Experiential Targeted Therapy – National

Trial TOASTIE
Cancer Type Miscellaneous
Hospital(s) Belfast City Hospital
Information

Tolerance Of Anti-cancer Systemic Therapy In the Elderly

Trial UK P3BEP
Cancer Type Genitourinary and Miscellaneous
Hospital(s) Belfast City Hospital
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A randomized phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours

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Trial UKALL 14
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

A randomised trial for adults with newly diagnosed acute lymphoblastic leukaemia

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Trial VICTOR
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
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Venetoclax or Intensive Chemotherapy For Treatment of Favourable Risk Acute Myeloid Leukaemia: A Molecularly Guided Phase 2 Study