Belfast City Hospital

Trial A Phase I trial of LY3143921 hydrate in solid tumours
Cancer Type Miscellaneous and Non-specific
Hospital(s) Belfast City Hospital
Information

A Cancer Research UK phase I trial of LY3143921 hydrate (a CDC7 inhibitor) given orally once daily in adult patients with advanced solid tumours

Trial Add-Aspirin Trial
Cancer Type Bowel Cancer, Gastrointestinal, Genitourinary, Miscellaneous, Oesophageal Cancer, Prostate Cancer, Stomach Cancer, and Non-specific
Hospital(s) Belfast City Hospital
Information

A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours

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Trial AML 18
Cancer Type Haematological Cancers, Leukaemia, and Other Haematological
Hospital(s) Belfast City Hospital
Information

AML 18 A Trial For Older Patients With Acute Myeloid Leukaemia And High Risk Myelodysplastic Syndrome

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Trial AMPLITUDE
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A Phase 3 Randomized, Placebo-controlled, Double-blind Study of Niraparib in Combination with Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants with Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Trial ANTHEM
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

The ANTHEM Feasibility Study, Is A Novel THErapeutic mammaplasty procedure a safe and effective alternative to Mastectomy for treatment of breast cancer?

Trial ASTEFANIA
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

A phase III, randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of adjuvant atezolizumab or placebo and trastuzumab emtansine for her2-positive breast cancer at high risk of recurrence following preoperative therapy

Trial BALLAD UK
Cancer Type Bowel Cancer and Gastrointestinal
Hospital(s) Belfast City Hospital
Information

A trial to evaluate the potential benefit of adjuvant chemotherapy for small bowel adenocarcinoma

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Trial CellCentric
Cancer Type Miscellaneous and Non-specific
Hospital(s) Belfast City Hospital
Information

An open-label Phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination in patients with advanced solid/metastatic tumours

Trial CellCentric CCS1477-01
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

An open-label Phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination in patients with advanced solid/metastatic tumours

Trial CHALLENGE
Cancer Type Bowel Cancer and Gastrointestinal
Hospital(s) Belfast City Hospital
Information

A phase III study of the impact of a physical activity programme on disease-free survival in patients with high risk stage II or stage III colon cancer: A randomised controlled trial

Trial CHAT
Cancer Type Kidney Cancer and Melanoma
Hospital(s) Belfast City Hospital
Information

Investigating the management and outcomes of patients who experience immune-related adverse events following treatment with immune checkpoint inhibitor therapy

Trial COMPARE
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

Phase III randomised controlled trial Comparing Alternative Regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer

Trial COSMIC 312
Cancer Type Gastrointestinal
Hospital(s) Belfast City Hospital
Information

A Randomized, Controlled Phase 3 Study of Cabozantinib (XL184) in Combination with Atezolizumab versus Sorafenib in Subjects with Advanced Hepatocellular Carcinoma Who Have Not Received Previous Systemic Anticancer Therapy

Trial CREST UK
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

CPX-351 Real-World Effectiveness and Safety Study

Trial DANTE
Cancer Type Melanoma
Hospital(s) Belfast City Hospital
Information

A randomised phase III trial to evaluate the Duration of ANti-PD1 monoclonal antibody Treatment in patients with metastatic mElanoma

Trial DIAdIC
Cancer Type Miscellaneous and Non-specific
Hospital(s) Belfast City Hospital
Information

Protocol for an International Randomized Controlled Trial to evaluate the effectiveness of a nurse-delivered (FOCUS+) and a web-based (iFOCUS) psychoeducational intervention for people with Advanced cancer and their family caregivers

Trial FAK-PD1
Cancer Type Miscellaneous and Non-specific
Hospital(s) Belfast City Hospital
Information

A Phase I/IIA Study to Assess Safety, Tolerability and Preliminary Activity of FAK (defactinib) and PD-1 (Pembrolizumab) Inhibition in Patients with Advanced Solid Malignancies

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Trial FLAIR
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Altnagelvin Hospital, Belfast City Hospital, and Craigavon Hospital
Information

Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab

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Trial HALT
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

Targeted therapy with or without dose intensified radiotherapy for oligo-progressive disease in oncogene-addicted lung tumours

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Trial ICHOR
Cancer Type Gastrointestinal, Oesophageal Cancer, and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

Investigation of Circulating Haematological Biomarkers in Cancer

Trial IMAT Neuroblastoma
Cancer Type Children’s Cancer
Hospital(s) Belfast City Hospital and Royal Belfast Hospital for Sick Children
Information

A randomised phase I/II study of Intensity Modulated Arc Therapy techniques in abdominal neuroblastoma

Trial Immune gene expression and tumour microenvironment in prostate cancer
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
Information

How does radiotherapy affect immune gene expression and the tumour microenvironment in men with localised prostate cancer?

Trial IMvigor011
Cancer Type Bladder Cancer
Hospital(s) Belfast City Hospital
Information

Phase III, double-blind, multicenter, randomized study of atezolizumab (anti-pd-l1 antibody) versus placebo as adjuvant therapy in patients with high-risk muscle-invasive bladder cancer who are ctDNA positive following cystectomy

Trial iNATT
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

The interNational Anaplastic Thyroid Cancer Tissue Bank and Database Project

Trial INTERLACE
Cancer Type Cervical Cancer and Gynaecological
Hospital(s) Belfast City Hospital
Information

A phase III multicentre trial of weekly induction chemotherapy followed by standard chemoradiation versus standard chemoradiation alone in patients with locally advanced cervical cancer

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Trial INTERVAL (GAP 4)
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Intense Exercise for Survival Among Men With Metastatic Castrate-Resistant Prostate Cancer (INTERVAL – MCRPC): A Multicenter, Randomised, Controlled, Phase III Study

Trial M16-109
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

A Phase II Open-Label Study Evaluating Tolerability And Efficacy of Navitoclax Alone or In Combination With Ruxolitinib in Subjects With Myelofibrosis

Trial Manifest
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

A Phase 1/2 Study of CPI-0610, a Small Molecule Inhibitor of BET
Proteins: Phase 1 (Dose Escalation of CPI-0610 in Patients with Haematological Malignancies) and Phase 2 (Dose Expansion of CPI-0610 with and without Ruxolitinib in Patients with Myelofibrosis)

Trial MK3475-937
Cancer Type Gastrointestinal
Hospital(s) Belfast City Hospital
Information

A Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant Therapy in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection or Local Ablation (KEYNOTE-937)

Trial MK3475-966
Cancer Type Gastrointestinal
Hospital(s) Belfast City Hospital
Information

A Phase 3 Randomized, Double Blind Study of Pembrolizumab Plus Gemcitabine/Cisplatin versus Placebo Plus Gemcitabine/Cisplatin as First-Line Therapy in Participants with Advanced and/or Unresectable Biliary Tract Carcinoma

Trial MONITOR-UK
Cancer Type Gynaecological and Ovarian Cancer
Hospital(s) Belfast City Hospital
Information

Multi-Centre Observational study of Maintenance Niraparib in Treatment of Ovarian CanceR: UK routine clinical practice experience

Trial MOSAICC
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

MyeloprOliferative NeoplasmS An In-Depth Case-Control Study: A Case-Control Study Of Patients With Myeloproliferative Neoplasms And Non-Blood Relative/Friend Controls

Trial NOSTRA
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

A prospective, non-randomised, multi-centre feasibility study to assess if patients residual cancer following dual-targeted neoadjuvant chemotherapy treatment for HER2-positive, ER-negative early breast cancer can be identified by multiple ultrasound-guided tumour bed core biopsies

Trial OCCAMS
Cancer Type Gastrointestinal and Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

Multicentre Study to determine Predictive and Prognostic Biomarkers and Therapeutic Targets for Oesophageal and Junctional Adenocarcinoma including whole genome sequencing

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Trial PACE
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

Patients with AML and COVID-19 Epidemiology

Trial PEARL
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

A window of opportunity study to assess the biological effects of progesterone in premenopausal ER-positive, PgR-positive early breast cancer

Trial PIONEER (Breast cancer)
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Randomised Phase II clinical trial PIONEER- A Pre-operative wIndOw study of Letrozole plus PR agonist (Megestrol Acetate) versus Letrozole aloNE in post-menopausal patients with ER-positive breast cancer

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Trial Pivotal Boost
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A Phase III Randomised Controlled Trial of Prostate and Pelvis Versus Prostate Alone Radiotherapy With Or Without Prostate Boost

Trial PLATFORM
Cancer Type Oesophageal Cancer and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

PLAnning Treatment For Oesophago-Gastric Cancer: a Randomised Maintenance Therapy Trial

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Trial PLATFORM
Cancer Type Gastrointestinal, Oesophageal Cancer, and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

PLAnning Treatment For Oesophago-Gastric Cancer: a Randomised Maintenance Therapy Trial

Trial Precision-Panc
Cancer Type Gastrointestinal and Pancreatic Cancer
Hospital(s) Belfast City Hospital
Information

Master Protocol Personalising Treatment For Pancreatic Cancer

Trial PRIMUS-001
Cancer Type Gastrointestinal and Pancreatic Cancer
Hospital(s) Belfast City Hospital
Information

An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation

Trial PROCADE
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A Multinational, Phase 3, Randomized, Double-Blind, Non-Inferiority, Efficacy and Safety Study of Oral HC-1119 versus Enzalutamide in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Trial PROTECTOR
Cancer Type Gynaecological and Ovarian Cancer
Hospital(s) Belfast City Hospital
Information

Preventing Ovarian Cancer through Early Excision of Tubes and late Ovarian Removal

Trial RANGO
Cancer Type Cervical Cancer, Endometrial (womb) Cancer, Gynaecological, Ovarian Cancer, and Vulval Cancer
Hospital(s) Belfast City Hospital
Information

Rare Neoplasms of Gynaecological Origin

Trial ROSCO
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Response To Optimal Selection Of Neo-Adjuvant Chemotherapy In Operable Breast Cancer

Trial SCOPE 2
Cancer Type Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

A randomised Phase II/III trial to study radiotherapy dose escalation in patients with
oesophageal cancer treated with definitive chemo-radiation with an embedded Phase II trial for patients
with a poor early response using positron emission tomography (PET)

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Trial SCOPE 2
Cancer Type Gastrointestinal and Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

A randomised Phase II/III trial to study radiotherapy dose escalation in patients with oesophageal cancer treated with definitive chemo-radiation with an embedded Phase II trial for patients with a poor early response using positron emission tomography (PET)

Trial SMALL Trial
Cancer Type Breast Cancer
Hospital(s) Altnagelvin Hospital, Belfast City Hospital, and Craigavon Hospital
Information

A Phase III, randomised, multi-centre trial addressing overtreatment of small screen-detected breast cancer by comparing standard surgery versus minimally invasive vacuum-assisted excision

Trial SPORT High-Risk Trial
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised Feasibility Study Evaluating Stereotactic Prostate Radio Therapy In High-Risk Localised Prostate Cancer With Or Without Elective Nodal Irradiation

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Trial Stampede
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Systemic Therapy in Advancing or Metastatic Prostate cancer – Evaluation of Drug Efficacy

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Trial SYSTEMS-2
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised Phase II Trial of Standard Versus Dose Escalated Radiotherapy in the Treatment of Pain in Malignant Pleural Mesothelioma

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Trial TARGET-National
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

Tumour Characterization to Guide Experiential Targeted Therapy – National

Trial Tidal Study
Cancer Type Haematological Cancers and Lymphoma
Hospital(s) Belfast City Hospital
Information

A Multicenter, Open-label, single-arm, Phase 2 Study of Zandelisib (ME401) in Subjects with Follicular Lymphoma or Marginal Zone Lymphoma After Failure of Two or More Prior Systemic Therapies

Trial TOASTIE
Cancer Type Miscellaneous
Hospital(s) Belfast City Hospital
Information

Tolerance Of Anti-cancer Systemic Therapy In the Elderly

Trial UK P3BEP
Cancer Type Genitourinary and Miscellaneous
Hospital(s) Belfast City Hospital
Information

A randomized phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours

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Trial UKALL 14
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

A randomised trial for adults with newly diagnosed acute lymphoblastic leukaemia

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Trial VICTOR
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

Venetoclax or Intensive Chemotherapy For Treatment of Favourable Risk Acute Myeloid Leukaemia: A Molecularly Guided Phase 2 Study