Belfast City Hospital

Trial Add-Aspirin Trial
Cancer Type Breast Cancer and Miscellaneous
Hospital(s) Belfast City Hospital and Craigavon Hospital
Information

A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours

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Trial AMMO
Cancer Type Haematological Cancers
Hospital(s) Belfast City Hospital
Information

A Randomised Phase II Study Of ASTX727 Versus Best Supportive Care In MDS/MPN Overlap Syndromes

Trial ANTHEM
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

The ANTHEM Feasibility Study, Is A Novel THErapeutic mammaplasty procedure a safe and effective alternative to Mastectomy for treatment of breast cancer?

Trial ASTEFANIA
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

A phase III, randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of adjuvant atezolizumab or placebo and trastuzumab emtansine for her2-positive breast cancer at high risk of recurrence following preoperative therapy

Trial ATNEC
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Axillary management in T1-3N1M0 breast cancer patients with needle biopsy proven nodal metastases
at presentation after neoadjuvant chemotherapy

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Trial Bayer 21343
Cancer Type Miscellaneous
Hospital(s) Belfast City Hospital
Information

An Open-Label, Phase Ib, Dose Escalation And Expansion Study To Evaluate The Safety, Tolerability, Maximum Tolerated Or Administered Dose, Pharmacokinetics, Pharmacodynamics And Efficacy Of The Aryl Hydrocarbon Receptor Inhibitor (AhRi) Bay 2416964 In Combination With Pembrolizumab In Participants With Advanced Solid Tumours

Trial CellCentric
Cancer Type Miscellaneous and Non-specific
Hospital(s) Belfast City Hospital
Information

An open-label Phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination in patients with advanced solid/metastatic tumours

Trial CellCentric CCS1477-01
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

An open-label Phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination in patients with advanced solid/metastatic tumours

Trial CLIN-60000-452
Cancer Type Kidney Cancer
Hospital(s) Belfast City Hospital
Information

A prospective observational international study of cabozantinib tablets in combination with nivolumab as first-line treatment of advanced renal cell carcinoma in adults

Trial COMPARE
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

Phase III randomised controlled trial Comparing Alternative Regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer

Trial CONCORDE
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

A platform study of DNA damage response inhibitors in combination with conventional radiotherapy in non small cell lung cancer

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Trial CT7001_003
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

A Phase 1b/2 Open-label Study of Samuraciclib in Combination with Elacestrant in Participants with Metastatic or Locally Advanced Hormone Receptor-positive and Human Epidermal Growth Factor Receptor 2-negative Breast Cancer

Trial DETERMINE
Cancer Type Miscellaneous
Hospital(s) Belfast City Hospital
Information

Determining Extended Therapeutic indications for Existing drugs in Rare Molecularly-defined Indications using a National Evaluation platform trial

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Trial DIAdIC
Cancer Type Miscellaneous and Non-specific
Hospital(s) Belfast City Hospital
Information

Protocol for an International Randomized Controlled Trial to evaluate the effectiveness of a nurse-delivered (FOCUS+) and a web-based (iFOCUS) psychoeducational intervention for people with Advanced cancer and their family caregivers

Trial EndoNET
Cancer Type Breast Cancer
Hospital(s) Altnagelvin Hospital and Belfast City Hospital
Information

Randomised controlled trial evaluating effectiveness of neoadjuvant endocrine treatment in post-menopausal women

Trial FEDORA
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

A Phase II Study To Evaluate The Tolerability, Safety And Activity Of Fedratinib Combined With Ropeginterferon Alfa-2b In Patients With Myelofibrosis

Trial FLAIR
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital and Craigavon Hospital
Information

Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab

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Trial HER2-RADiCAL
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

The HER2-RADiCAL study (Response ADaptive CAre pLan) – Tailoring treatment for HER2 positive early breast cancer

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Trial ICHOR
Cancer Type Gastrointestinal, Oesophageal Cancer, and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

Investigation of Circulating Haematological Biomarkers in Cancer

Trial Immune gene expression and tumour microenvironment in prostate cancer
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
Information

How does radiotherapy affect immune gene expression and the tumour microenvironment in men with localised prostate cancer?

Trial IMPARTER:4
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

IMproving PAtient undeRstanding of GEP TEst Results: Phase 4

Trial iNATT
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

The interNational Anaplastic Thyroid Cancer Tissue Bank and Database Project

Trial M16-109
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

A Phase II Open-Label Study Evaluating Tolerability And Efficacy of Navitoclax Alone or In Combination With Ruxolitinib in Subjects With Myelofibrosis

Trial MARECA
Cancer Type Breast Cancer
Hospital(s) Altnagelvin Hospital, Belfast City Hospital, and Craigavon Hospital
Information

National study of management of breast cancer locoregional recurrence and oncological outcome

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Trial MITHRIDATE
Cancer Type Haematological Cancers
Hospital(s) Belfast City Hospital
Information

A phase III, randomised, open-label, Multicenter International Trial comparing ruxolitinib with either HydRoxycarbamIDe or interferon Alpha as first line ThErapy for high risk polycythemia vera

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Trial MONITOR-UK
Cancer Type Gynaecological and Ovarian Cancer
Hospital(s) Belfast City Hospital
Information

Multi-Centre Observational study of Maintenance Niraparib in Treatment of Ovarian CanceR: UK routine clinical practice experience

Trial MOSAICC
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Antrim Hospital, Belfast City Hospital, Craigavon Hospital, and Ulster Hospital
Information

MyeloprOliferative NeoplasmS An In-Depth Case-Control Study: A Case-Control Study Of Patients With Myeloproliferative Neoplasms And Non-Blood Relative/Friend Controls

Trial NERO
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

Niraparib Efficacy in patients with unResectable MesotheliOma: A randomised phase II trial of Niraparib versus active symptom control in patients with previously treated mesothelioma

Trial NG11-2-P1b
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

A Phase-1b Dose Escalation Study to Assess the Effect of NG11-2 on Radiation Induced Oral Mucositis in Patients with Head & Neck Cancer

Trial NOSTRA
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

A prospective, non-randomised, multi-centre feasibility study to assess if patients residual cancer following dual-targeted neoadjuvant chemotherapy treatment for HER2-positive, ER-negative early breast cancer can be identified by multiple ultrasound-guided tumour bed core biopsies

Trial PACE
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

Patients with AML and COVID-19 Epidemiology

Trial PACE-NODES
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A phase III randomised trial of 5 fraction prostate SBRT versus 5 fraction prostate and pelvic nodal SBRT

Trial PACIFIC-9
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

A Phase III, double-blind, placebo-controlled, Randomized, Multicentre, International Study of Durvalumab Plus Oleclumab and Durvalumab Plus Monalizumab in Patients with Locally Advanced (Stage III), Unresectable, Non-small Cell Lung Cancer (NSCLC) Who Have Not Progressed Following Definitive, Platinum-Based Concurrent Chemoradiation Therapy

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Trial PEARL
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

A window of opportunity study to assess the biological effects of progesterone in premenopausal ER-positive, PgR-positive early breast cancer

Trial Pivotal Boost
Cancer Type Genitourinary and Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A Phase III Randomised Controlled Trial of Prostate and Pelvis Versus Prostate Alone Radiotherapy With Or Without Prostate Boost

Trial PLATFORM
Cancer Type Oesophageal Cancer and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

PLAnning Treatment For Oesophago-Gastric Cancer: a Randomised Maintenance Therapy Trial

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Trial PLATFORM
Cancer Type Gastrointestinal, Oesophageal Cancer, and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

PLAnning Treatment For Oesophago-Gastric Cancer: a Randomised Maintenance Therapy Trial

Trial POETIC-A
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Pre-Operative Endocrine Therapy for Individualised Care with Abemaciclib

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Trial Pola-R-ICE
Cancer Type Lymphoma
Hospital(s) Belfast City Hospital
Information

An open-label, prospective Phase III clinical study to compare polatuzumab vedotin plus rituximab, ifosfamide, carboplatin and etoposide (Pola-R-ICE) with rituximab, ifosfamide, carboplatin and etoposide (R-ICE) alone as salvage therapy in patients with primary refractory or relapsed diffuse large B-cell lymphoma (DLBCL)

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Trial Precision-Panc
Cancer Type Gastrointestinal and Pancreatic Cancer
Hospital(s) Belfast City Hospital
Information

Master Protocol Personalising Treatment For Pancreatic Cancer

Trial PRIMUS-001
Cancer Type Gastrointestinal and Pancreatic Cancer
Hospital(s) Belfast City Hospital
Information

An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation

Trial PRiZM+
Cancer Type Haematological Cancers and Lymphoma
Hospital(s) Belfast City Hospital
Information

A phase II platform study of zanubrutinib monotherapy and combination therapy for relapsed and refractory primary CNS lymphoma

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Trial PROMISE
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

Investigation Into The Combination Of PLX2853 With Ruxolitinib In Patients With Intermediate-2 Or High Risk Myelofibrosis Not Receiving An Adequate Response With Ruxolitinib Alone

Trial PROTECTOR
Cancer Type Gynaecological and Ovarian Cancer
Hospital(s) Belfast City Hospital
Information

Preventing Ovarian Cancer through Early Excision of Tubes and late Ovarian Removal

Trial PSMAddition
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

An International Prospective Open-Label, Randomised, Phase 3 Study Comparing 177Lu-PSMA-617 In Combination With Standard of Care, Versus Standard Of Care Alone, In Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer

Trial RE-ARM
Cancer Type Bladder Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised phase II trial of Enhancement of efficacy of Atezolizumab by Radiotherapy in Metastatic urothelial carcinoma

Trial SABRE
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Effectiveness of the SpaceOAR Vue System in Subjects with Prostate Cancer being Treated with Stereotactic Body RadiothErapy

Trial SCOPE 2
Cancer Type Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

A randomised Phase II/III trial to study radiotherapy dose escalation in patients with
oesophageal cancer treated with definitive chemo-radiation with an embedded Phase II trial for patients
with a poor early response using positron emission tomography (PET)

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Trial SCOPE 2
Cancer Type Gastrointestinal and Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

A randomised Phase II/III trial to study radiotherapy dose escalation in patients with oesophageal cancer treated with definitive chemo-radiation with an embedded Phase II trial for patients with a poor early response using positron emission tomography (PET)

Trial SMALL Trial
Cancer Type Breast Cancer
Hospital(s) Altnagelvin Hospital, Belfast City Hospital, and Craigavon Hospital
Information

A Phase III, randomised, multi-centre trial addressing overtreatment of small screen-detected breast cancer by comparing standard surgery versus minimally invasive vacuum-assisted excision

Trial STELLAR
Cancer Type Haematological Cancers and Lymphoma
Hospital(s) Belfast City Hospital
Information

A phase II, randomiSed study of CHOP-R in combination with acalabruTinib comparEd to CHOP-R in patients with newLy diagnosed Richter’s Syndrome and a pLAtfoRm for initial investigations into activity of novel treatments in relapsed/refractory and newly diagnosed Richter’s Syndrome

Trial TARGET-National
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

Tumour Characterization to Guide Experiential Targeted Therapy – National

Trial TOASTIE
Cancer Type Miscellaneous
Hospital(s) Belfast City Hospital
Information

Tolerance Of Anti-cancer Systemic Therapy In the Elderly

Trial UK P3BEP
Cancer Type Genitourinary and Miscellaneous
Hospital(s) Belfast City Hospital
Information

A randomized phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours

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Trial UKALL 14
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

A randomised trial for adults with newly diagnosed acute lymphoblastic leukaemia

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Trial VICTOR
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

Venetoclax or Intensive Chemotherapy For Treatment of Favourable Risk Acute Myeloid Leukaemia: A Molecularly Guided Phase 2 Study